Aims: Head and neck cancer (HNC) affects vital functions including speech, swallowing, breathing, and cosmesis, resulting in long term health needs and health service utilisation. HNC survivors may experience financial toxicity associated with treatment and survivorship. We aimed to explore the financial burden of HNC in Australia as experienced by patients, caregivers, and clinicians. Methodology: A national sample of participants was recruited through social media and hospital clinics. Participants were purposively sampled for representativeness of tumour site, gender, age, and geographic location. Semi-structured interviews were conducted via phone and videoconferencing. Interviews (audio-recordings and written responses) were transcribed and analysed using reflexive thematic analysis. Results: Interviews were completed with 47 participants (22 patients, 9 caregivers, 16 clinicians). Participants (excluding clinicians) were mostly female (61%), with median age 59, and the most common tumour site was the oral cavity. Participants recalled highest costs being incurred during the post-operative period and related to the nature and length of recovery, specialist appointments, modified diet, travel, medication and inability to work. Several participants cited ongoing costs associated with dental care, often deciding to delay or forgo dental treatment altogether. The specific importance of social workers and nurses providing information about financial support services was highlighted, however for many these services were never discussed. Clinicians acknowledged patients’ financial burden but noted limited resources to guide conversations with patients and caregivers. Conclusion: For most HNC survivors the greatest financial burden relates to treatment side-effects and dental care. Our findings highlight the need for resources to guide clinician-led discussion of financial concerns, with emphasis on the need to reach groups at highest risk of financial toxicity.